What is Regenerative Medicine

Regenerative medicine is an innovative method of harnessing your own body’s healing cells or tissue (PRP or Stem Cells) to repair damages to your joints, tendons, muscles or spine without surgery. Most commonly used tissue are Platelet Rich Plasma and Bone Marrow Mesenchymal stem cells. We use Plasma Rich Platelets or Bone Marrow Stem Cells from your own body and concentrate them and inject your concentrated cells or PRP into the damaged tissue to accelerate healing, relieve pain and strengthen the healing tissue. Currently use of Umbilical cord stem cells or stem cells from other person is not approved by FDA for general use.

Treatments

Platelet Rich Plasma (PRP) Injections

Platelet Rich Plasma (PRP) is extracted from your own blood. The platelets are concentrated using special machines to yield a solution of very concentrated platelet solution. PRP contains approximately 20 different growth factors, anti-inflammatory factors and chemical mediators that promotes the repair of damaged cell and helps it healing. We concentrate these platelets into small volume and inject the solution into injured or damaged tissue maximizing the delivery of the growth factors and chemical factors to promote repair and healing. It improves blood supply and gives the damaged tissue all the substances necessary for healing. It not only promotes healing but helps a faster and better healing of tissue. Dr Boddu uses FDA approved state of the art machines to extract PRP. These machines improve the platelet extraction and concentration ability providing a superior PRP. These processes are performed in an aseptic environment during the extraction process and injection.

Stem Cell Therapy

Stem Cells are body’s foundational material that can develop into range of different cells with specialized functions. They help the repair of damaged tissue or transforms into the target tissue. Stem Cells helps damaged tissue repair by secreting exosomes, growth factors, anti-inflammatory factor, immunomodulation, paracrine cell signaling and transformation into the targeted tissue. There are many types of stemcells. Most common mesenchymal stemcells used are Bone Marrow Stem Cells and Adipose tissues Stem cells. Bone Marrow stemcells can be obtained by aspirating your bone marrow from back of your pelvic bone. It is crucial to perform appropriate aspiration technique to obtain high number of the bone marrow stem cells. Dr Boddu Published artlcle regarding bone marrow aspiration technique for maximizing the Bone marrow stem cell count. Your bone marrow is processed in FDA approved state of art machine to extract Bone Marrow Concentrates, these concentrates contain your own Bone Marrow Mesenchymal stem cells. These stem cell concentrate can be injected into Joints (shoulder, knee, elbow, hip and ankle) or into spine Disc, Facet joints or SI joint to help and fasten healing. These new nonsurgical techniques will help healing, relieve pain and restore function.

Adipose stem cells are obtained from you own body fat. Dr Boddu suctions fat from your body and uses the fat to obtain stem cells. The stem cells are present in stromal vascular fraction (SVF), Dr Boddu uses methods that comply with FDA guidelines obtain the adipose stem cells. After isolating the stem cells are injected into the damaged tissue like joints and spine. These stem cells helps body heal without altering the natural anatomy.

Questions and Answers Regarding Stem Cells

  • Stem cells are the building blocks of our bodies. They help create new tissue in areas that have been injured or damaged, and they are able to repair certain parts like joints with cartilage problems. Stem cells have the potential to be transformed into any type of cell in your body.

    Stem cells are different from other cells in that they have self-renewing abilities, can grow for an extended period of time and differentiate into specialized tissue. These characteristics make stem cell therapy very promising as it has the potential to help people with certain conditions like injuries or diseases affecting specific parts within their body. Stem cells can be transformed into a wide-variety of different cells. These include: cardiac cells, liver cells, fat cells, bone cells, cartilage cells, nerve cells, and connective tissue cells.

  • There are multiple types of stem cells all coming from different parts of the body. Adult stem cells, or also referred to as tissue-specific cells, these stem cells have not been identified in all tissues and organs, but in many cases they do exist and have a confirmed role in repairing and maintaining tissue that has been injured or damaged by disease. The stem cells used by Dr Boddu come from your own body. The stem cells are present abundantly in your bone marrow and your fat tissue. These are the only stem cells approved by the FDA for clinical use in the USA.

  • Stem cells are unspecialized cells that have not yet taken on a specific job in the body. They can become any other type of cell in the body, so they have the potential to treat a wide variety of diseases. Stem cells have homing effect, it means the cells seek the damaged tissue or tissue in distress and congregate in very high numbers and start healing the tissue.

    When using stem cells to treat joint and arthritis pain, stem cells work primarily by secreting very powerful anti-inflammatory proteins. This helps to reduce inflammation and pain. These proteins are more effective than any man-made anti-inflammatory medication on the market, the results are organic, and long lasting. Stem cells are also very intelligent, and they secrete customized anti-inflammatory proteins that the joint needs.

    By rejuvenating dying cells, regeneration of the joint is also seen. However, this regeneration is seen mostly at a microscopic level. Stem cells also cause “Immunomodulation”. What this means is that they prevent arthritis in the joint from getting worse.

  • For stem cell therapy that reduces joint, back, and arthritis pain, there are two main qualifiers for stem cell therapy.

    1. The pain in the back or the joint should be severe enough that it is affecting the patients’ lifestyle. If the pain is not severe, stem cells do not get activated and the procedure does not work.

    2. Since stem cell therapy is not covered by insurance, patients should be capable of affording it.

    If you are a candidate for a joint replacement or spinal fusion, consider stem cell therapy. The most important reason is that you can always have surgery if stem cell therapy fails. Unfortunately, if surgery fails it becomes more difficult to perform stem cell therapy.

  • Dr Boddu uses only adult stem cells that are found in the bone marrow or your adipose tissue. This type of stem cell is FDA compliant and has the lowest risk of infection and other very low possible side effects as they are coming from your own body.

    We use this type of cell because adult stem cells have unique abilities that allow them to differentiate into specialized cell types and self-renew. In the body, adult stem cells serve as a repair system for various tissues such as skin, blood, and gut epithelium by regenerating new cells when our own tissue is damaged or diseased. Adult stem cells can become any kind of cell with a particular function needed by the specialized tissue they reside in. This ability to change into different cell types is called differentiation and it is one of the most important properties of adult stem cells.

  • Most organs contain stem cells, called adult stem cells, that persist throughout life and contribute to the maintenance and repair of those organs. Not every organ has been shown to contain these cells, and generally adult stem cells have restricted developmental potential, in that their capacity for proliferation is limited and they can give rise only to a few cell types. Embryonic stem cells, by contrast, can divide almost indefinitely and can give rise to every cell type in the body, suggesting that they may be the most versatile source of cells for research and transplantation therapy. Use of embryonic stem cells is illegal in the USA.

  • Most patients get good results with stem cell therapy. Not everyone responds to it. In our clinic we are seeing 70-80% of patients get excellent results. Many clinical studies are showing that this procedure helps with back pain and knee pain. These studies also did not report any complications.

  • Fortunately, patients get many years of relief from this procedure. In one back pain study, even after 5 years, patients continued to see pain relief. In one knee study, pain did not come back even after 12 years. Since it is a new procedure, we do not know the upper limit of the duration of pain relief.

  • Generally you will be sedated during the procedure, your pain during the procedure will be minimal. However, if your discs or bone are injected, you may have a flare up for a few days. Dr Boddu, we treat this pain aggressively with pain killers after the procedure

  • Multiple studies have shown that there are no major complications of stem cells when used to treat back pain and joint pain.

    However, complications have been reported if

    1. Umbilical cord stem cells have been used

    2. Procedure is performed by poorly qualified providers

    3. Stem cells have been injected in the wrong areas

    Hence, it is absolutely crucial that you do your research and get the stem cell therapy at the clinic.

  • To give you the best results, legitimate clinics extract stem cells from your bone marrow and are injected precisely into the areas of pain by a qualified physician.

    To maximize results, meticulous, time-consuming bone marrow aspiration must be done to get a large number of stem cells. Using a quick bone marrow aspiration technique will compromise the number of stem cells extracted. Dr Boddu co-authored an article, and wrote a chapter about bone marrow stem cell extraction and concentration.

    Additionally, the right areas must be injected. For example, if you want the best results for back pain, lumbar disc has to be injected. In patients with severe joint pain, the bone of the joint is usually damaged. This bone has to be injected to get the best result.

    Results from this procedure also depend directly on the quality of the physician performing the therapy.

    This procedure usually takes around 2 hours. If the procedure is NOT performed in this fashion, you will NOT see good long term results. These clinics usually charge the patients $4000 to $6000.